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Termination of transcription by nusA gene protein of Escherichia coli

Nature volume 292, pages 215–220 (1981)Cite this article

Abstract

The nusA gene protein of Escherichia coli and N gene protein of bacteriophage γ interact in vitro and cooperate in vivo to prevent transcription termination. In vitro the nusA gene protein causes RNA polymerase to pause in the tR2 terminator region of γ DNA. A completed termination event at tR2 requires both the nusA gene protein and the previously described E. coli termination factor rho. The nusA gene protein is therefore both a transcription termination factor and a protein which couples antitermination factors to the elongating transcription complex.

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Authors and Affiliations

  1. Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada, M5G 1L6

    Jack Greenblatt, Marjorie McLimont & Sarah Hanly

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  2. Marjorie McLimont
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  3. Sarah Hanly
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Greenblatt, J., McLimont, M. & Hanly, S. Termination of transcription by nusA gene protein of Escherichia coli. Nature 292, 215–220 (1981). https://doi.org/10.1038/292215a0

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