Abstract
In 20% of cases of secondary amenorrhoea, hyperprolactinaemia prevents ovulation by impairing normal follicular development, but little is known of the biochemical basis for this effect1. Bromocriptine can restore follicular growth and ovulation2 by inhibiting the release of prolactin from the pituitary. The suckling stimulus causes an increase in prolactin levels3, and ovarian follicles fail to develop fully, thus inducing an anovulatory state throughout lactation in many mammals. We report here experiments with cultured granulosa cells which suggest that this contraceptive action of prolactin is due to its ability to interfere with the action of follicle-stimulating hormone (FSH) on the synthesis of oestrogen.
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References
McNeilly, A. S. Nature 284, 212 (1980).
Besser, G. M., Parke, L., Edwards, C. R. W., Forsyth, I. A. & McNeilly, A. S. Br. med. J. 3, 669 (1972).
Frantz, A. G., Kleinberg, D. L. & Noel, G. L. Recent Prog. Horm. Res. 28, 527 (1972).
Engel, L. in Handbook of Physiology Vol. 2, Part 1 (eds Greep, R. O. & Astwood, E. B.) 467 (Am. Physiol. Soc., Washington DC, 1973).
Gore-Langton, R. E. & Dorrington, J. H. Molec. Cell Endocr. (in the press).
Dorrington, J. H., Moon, Y. S. & Armstrong, D. T. Endocrinology 97, 1328 (1975).
McNatty, K. P., Hunter, W. M., McNeilly, A. S. & Sawers, R. S. J. Endocr. 64, 555 (1975).
Richards, J. S. & Williams, J. J. Endocrinology 99, 1571 (1976).
Wang, C., Hsueh, A. J. W. & Erickson, G. F. J. biol. Chem. 254, 11330–11336 (1979).
McNatty, K. P., Sawers, R. & McNeilly, A. S. Nature 250, 653 (1974).
Velhuis, J. D., Klase, P. & Hammond, J. M. Endocrinology 107, 42–46 (1980).
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Dorrington, J., Gore-Langton, R. Prolactin inhibits oestrogen synthesis in the ovary. Nature 290, 600–602 (1981). https://doi.org/10.1038/290600a0
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DOI: https://doi.org/10.1038/290600a0
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