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Generation of F1 hybrid cytotoxic T lymphocytes specific for self H–2

Nature volume 289, pages 559–563 (1981)Cite this article

Abstract

Cytotoxic T lymphocytes specific for self H–2 antigens are generated by murine F1 hybrid (H–2 heterozygous) spleen cells cultured with irradiated parental (H–2 homozygous) splenocytes. The effectors bind to heterozygous and homozygous cells bearing the appropriate H–2 alleles but only lyse homozygous targets. Autoreactivity for membrane-bound molecules of normal cells may be a mechanism for regulating cellular interactions.

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Authors and Affiliations

  1. Departments of Pathology and Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York, 14214

    Keiichiro Nakano, Ichiro Nakamura & Gustavo Cudkowicz

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  1. Keiichiro Nakano
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  2. Ichiro Nakamura
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  3. Gustavo Cudkowicz
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Nakano, K., Nakamura, I. & Cudkowicz, G. Generation of F1 hybrid cytotoxic T lymphocytes specific for self H–2. Nature 289, 559–563 (1981). https://doi.org/10.1038/289559a0

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