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Intrachromosomal gene conversion in yeast

Nature volume 289, pages 144–148 (1981)Cite this article

Abstract

We have shown that the yeast Saccharomyces cerevisiae has a mechanism by which information from one gene can be transferred non-reciprocally to a repeated copy of the gene on the same chromosome. This intrachromosomal gene conversion may be important in maintaining sequence homogeneity within families of repeated eukaryotic genes.

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References

  1. Petes, T. D. Cell 19, 765–774 (1980).

    Article  CAS  Google Scholar 

  2. Szostak, J. W. & Wu, R. Nature 84, 426–430 (1980).

    Article  ADS  Google Scholar 

  3. Tartof, K. D. Cold Spring Harb. Symp. quant. Biol. 38, 491–500 (1973).

    Article  Google Scholar 

  4. Latt, S. A. & Schreck, R. R. Am. J. hum. Genet. 32, 297–313 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Beggs, J. D., Guerineau, M. & Atkins, J. F. Molec. gen. Genet. 148, 287–294 (1976).

    Article  CAS  Google Scholar 

  6. Guerineau, M., Grandchamp, C. & Slonimski, P. P. Proc. natn. Acad. Sci. U.S.A. 73, 3030–3034 (1976).

    Article  ADS  CAS  Google Scholar 

  7. Hollenberg, C. P., Degelman, A., Kustermann-Kuhn, B. & Roger, H. D. Proc natn. Acad. Sci. U.S.A. 73, 2072–2076 (1976).

    Article  ADS  CAS  Google Scholar 

  8. Gubbins, E. J., Newlon, C. S., Kann, M. D. & Donelson, J. E. Gene 1, 185–207 (1977).

    Article  CAS  Google Scholar 

  9. Livingston, D. M. & Klein, H. L. J. Bact. 129, 472–481 (1977).

    CAS  Google Scholar 

  10. Strathern, J., Newlon, C., Herskowitz, I. & Hicks, J. Cell 18, 309–319 (1979).

    Article  CAS  Google Scholar 

  11. Hinnen, A., Hicks, J. & Fink, G. R. Proc. natn. Acad. Sci. U.S.A. 75, 1929–1933 (1978).

    Article  ADS  CAS  Google Scholar 

  12. Hicks, J., Strathern, J. & Herskowitz, I. DNA Insertion Elements, Plasmids and Episomes (eds Bukhari, A. I., Shapiro, J. A. & Adhya, S. L.) 457–462 (Cold Spring Harbor Laboratory, New York, 1977).

  13. Klar, A. J. S. & Fogel, S. Proc. natn. Acad. Sci. U.S.A. 76, 4539–4543 (1979).

    Article  ADS  CAS  Google Scholar 

  14. Bolivar, F. et al. Gene 2, 95–113 (1977).

    Article  CAS  Google Scholar 

  15. Mortimer, R. K. & Hawthorne, D. C. The Yeasts Vol. I (eds Rose, A. M. & Harrison, J. S.) 286–460 (Academic, London, 1969).

    Google Scholar 

  16. Southern, E. J. molec. Biol. 98, 503–518 (1975).

    Article  CAS  Google Scholar 

  17. Roman, H. & Jacob, F. Cold Spring Harb. Symp. quant. Biol. 23, 155–160 (1958).

    Article  CAS  Google Scholar 

  18. Meselson, M. S. & Radding, C. N. Proc. natn. Acad. Sci. U.S.A. 72, 358–361 (1975).

    Article  ADS  CAS  Google Scholar 

  19. Smith, G. P. Cold Spring Harb. Symp. quant. Biol. 38, 507–513 (1973).

    Article  Google Scholar 

  20. Hood, L., Campbell, J. H. & Elgin, S. C. R. A. Rev. Genet. 9, 305–353 (1975).

    Article  CAS  Google Scholar 

  21. Lauer, J., Shen, C. -K. J. & Maniatis, T. Cell 20, 119–130 (1980).

    Article  CAS  Google Scholar 

  22. Zimmer, E. A., Martin, S. K., Beverly, S. M., Kan, Y. W. & Wilson, A. C. Proc. natn. Acad. Sci. U.S.A. 77, 2158–2162 (1980).

    Article  ADS  CAS  Google Scholar 

  23. Goossens, M. et al. Proc. natn. Acad. Sci. U.S.A. 77, 518–521 (1980).

    Article  ADS  CAS  Google Scholar 

  24. Manning, R. F. & Gage, L. P. J. biol. Chem. (in the press).

  25. Jeffreys, A. J. Cell 18, 1–10 (1979).

    Article  CAS  Google Scholar 

  26. Slightom, J. L., Blechl, A. E. & Smithies, O. Cell 21, 627–638 (1980).

    Article  CAS  Google Scholar 

  27. Munz, P. & Leupold, U. Alfred Benzon Symp. 16 (in the press).

  28. Scherer, S. & Davis, R. W. Science 209, 1380–1384 (1980).

    Article  ADS  CAS  Google Scholar 

  29. Williamson, D. H. & Fennel, D. J. Meth. Cell Biol. 12, 335–351 (1975).

    Article  CAS  Google Scholar 

  30. Schachat, F. W. & Hogness, D. S. Cold Spring Harb. Symp. quant. Biol. 38, 371–381 (1973).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, The University of Chicago, 920 East 58th street, Chicago, Illinois, 60637

    Hannah L. Klein & Thomas D. Petes

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  1. Hannah L. Klein
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  2. Thomas D. Petes
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Klein, H., Petes, T. Intrachromosomal gene conversion in yeast. Nature 289, 144–148 (1981). https://doi.org/10.1038/289144a0

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