Abstract
Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A)1 and histamine2, are preferentially chemotactic for eosinophils in vitro. Amino acid substitutions or modifications of the ECF-A tetrapeptides may substantially alter the chemotactic activity of human eosinophils3. The cellular mechanism whereby ECF-A tetrapeptides enhance IgG-dependent killing of schistosomula by rat eosinophils4 is, however, unclear. We now report that the parent tetrapeptides and the substituted analogue Val-Pro-Ser-Glu (Pro3), but not histamine, increase the number of rat and human eosinophils that form rosettes with erythrocytes bearing IgG antibodies. Moreover, we find a correlation between the effect of these substances on the expression of rat eosinophil IgG Fc receptors and their capacity to increase the IgG-dependent cytotoxicity of rat eosinophils for Schistosoma mansoni schistosomula.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Goetzl, E. J. & Austen, K. F. Proc. natn. Acad. Sci. U.S.A. 72, 4123–4127 (1975).
Clark, R. A. F., Gallin, J. I. & Kaplan, A. P. J. exp. Med. 142, 1462–1476 (1975).
Smith, J. A., Goetzl, E. J. & Austen, K. F. in Peptides: Structure and Biological Function (eds Meienhofer, J. & Gross, E.) (Pierce Chemical Co., Rockford, Illinois, in the press).
Capron, M., Rousseaux, J., Mazingue, C., Bazin, H. & Capron, A. J. Immun. 121, 2518–2525 (1978).
Vadas, M., David, J. R. Butterworth, A. E., Pisani, N. T. & Siongok, T. A. J. Immun. 122, 1228–1236 (1979).
Capron, M., Torpier, G. & Capron, A. J. Immun. 123, 2220–2230 (1979).
Butterworth, A. E., Coombs, R. R. A., Gurner, B. W. & Wilson, A. B. Int. Archs Allergy appl. Immun. 51, 368–377 (1976).
Anwar, A. R. E. & Kay, A. B. Nature 269, 522–524 (1977).
Anwar, A. R. E. & Kay, A. B. J. Immun. 121, 1245–1250 (1978).
Kay, A. B. J. Allergy clin. Immun. 64, 90–104 (1979).
Capron, M., Goetzl, E. J., Austen, K. F. & Capron, A. Prog. Immun. (in the press).
Shields, J. M. & Wilkinson, P. C. Clin. exp. Immun. 38, 598–608 (1979).
Tai, P. C. & Spry, C. J. F. Clin. exp. Immun. 40, 206–219 (1980).
Lynch, S. M., Austen, K. F. & Wasserman, S. I. J. Immun. 121, 1394–1399 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Capron, M., Capron, A., Goetzl, E. et al. Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor. Nature 289, 71–73 (1981). https://doi.org/10.1038/289071a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/289071a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
