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Isolation and structure of a human fibroblast interferon gene

Nature volume 285, pages 542–547 (1980)Cite this article

Abstract

Chimaeric plasmids containing double-stranded cDNA copies of mRNA induced in human fibroblasts by poly I · C were screened by an RNA selection method. A series of clones to which human fibroblast interferon mRNA selectively hybridized was identified. From the nucleotide sequence of the gene, the complete amino acid sequence of human fibroblast interferon was deduced. The protein is 166 amino acids long and is preceded by a 21-amino acid signal sequence.

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Authors and Affiliations

  1. Laboratory of Molecular Biology, State University of Ghent, Ledeganckstraat 35, B-9000, Ghent, Belgium

    Rik Derynck, Guido Volckaert, Jan Tavernier, René Devos & Walter Fiers

  2. Institut Pasteur du Brabant, rue du Remorqueur 28, B-1040, Brussels, Belgium

    Jean Content

  3. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium

    Erik DeClercq

Authors
  1. Rik Derynck
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  2. Jean Content
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  3. Erik DeClercq
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  4. Guido Volckaert
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  5. Jan Tavernier
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  6. René Devos
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  7. Walter Fiers
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Derynck, R., Content, J., DeClercq, E. et al. Isolation and structure of a human fibroblast interferon gene. Nature 285, 542–547 (1980). https://doi.org/10.1038/285542a0

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