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2H NMR study of molecular motion in collagen fibrils

Nature volume 284, pages 531–534 (1980)Cite this article

Abstract

Collagen was labelled through tissue culture with [3,3,3-d3]alanine. 2HNMR spectra were obtained of the labelled collagen as fibrils and in solution using the quadrupolar echo technique for solids. The 2HNMR data were analysed in terms of a model for reorientation in which the molecule is considered to jump between two orientations in a time which is short compared to the residence time in each site, and short compared to (Δvq)−1. The best fit of the data indicates that the collagen molecule in the fibrils experiences reorientation about its long axis over an angular range of ∼30–40°. The T2 for [3,3,3-d3]alanine-labelled collagen fibrils is estimated to be ∼110 μS.

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Authors and Affiliations

  1. Laboratory of Biochemistry, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20205

    Lynn W. Jelinski, C. E. Sullivan & D. A. Torchia

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  1. Lynn W. Jelinski
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  2. C. E. Sullivan
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  3. D. A. Torchia
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Jelinski, L., Sullivan, C. & Torchia, D. 2H NMR study of molecular motion in collagen fibrils. Nature 284, 531–534 (1980). https://doi.org/10.1038/284531a0

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