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Orthotopic bone induction at sites of Moloney murine sarcoma virus inoculation in mice

Nature volume 281, pages 386–387 (1979)Cite this article

Abstract

Moloney murine sarcoma virus (M-MSV) induces at the site of inoculation in newborn1,2 and adult3–5 mice and rats various types of sarcoma1,6, including osteosarcoma7,8. The induced tumours are fatal in newborn mice3,9, whereas sarcomas developed in adult animals regress spontaneously3,5,10–12. The regression is mediated mainly by a cellular response3,5,10–12. We have now demonstrated that the presence of sarcomas induced by M-MSV is a powerful stimulus for periosteal osteogenesis around tumour masses. Orthotopically induced osteogenesis by M-MSV may serve as a model for local regulation of bone growth and for cell differentiation studies, and may help explain the aetiology of some human bone disorders.

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Authors and Affiliations

  1. Department of Histology and Embryology,

    K. Wlodarski

  2. Department of Virology, Institute of Biostructure, Medical School, Warsaw, Poland

    M. Kobus & M. Luczak

Authors
  1. K. Wlodarski
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  2. M. Kobus
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  3. M. Luczak
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Wlodarski, K., Kobus, M. & Luczak, M. Orthotopic bone induction at sites of Moloney murine sarcoma virus inoculation in mice. Nature 281, 386–387 (1979). https://doi.org/10.1038/281386a0

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