Abstract
Mammalian luteinising hormone (LH) is an association of two dissimilar subunits, α and β. In vitro studies, mainly using difference spectrophotometry, had shown that this phenomenon was slow, especially at low temperatures. If the situation was the same in poikilotherms, it would probably make gonadotropin (GTH) synthesis difficult for these animals in a cold environment. We have found that the formation of a teleost gonadotropin is in fact strikingly more rapid and less thermodependent than formation of mammalian LH. Also, studies with a fish–mammal hybrid molecule have allowed us to estimate the respective influence of the α and β subunits in determining these differences.
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References
De la Llosa, P. & Jutisz, M. Biochim. biophys. Acta 181, 426–436 (1969).
Pernollet, J. C. & Garnier, J. FEBS Lett. 18, 189–192 (1971).
Ingham, K. C., Aloj, S. M. & Edelhoch, H. Archs Biochem. Biophys. 159, 596–605 (1973).
Salesse, R., Castaing, M., Pernollet, J. C. & Garnier, J. J. molec. Biol. 95, 483–496 (1975).
Burzawa-Gerard, E. C. r. hebd Séanc. Acad. Sci., Paris, Sér. D 279, 1681–1684 (1974).
Jolles, J., Burzawa-Gerard, E., Fontaine, Y. A. & Jolles, P. Biochimie 59, 893–898 (1977).
Garnier, J. in Structure and Function of the Gonadotropins (ed. McKerns, K. W.) 381–414 (Plenum, New York, 1978).
Marchelidon, J. et al. C. r. hebd Séanc. Acad. Sci., Paris Sér, D 287, 301–304 (1978).
Fontaine, Y. A. & Burzawa-Gerard, E. in Structure and Function of the Gonadotropins (ed. McKerns, K. W.) 361–380 (Plenum, New York, 1978).
Burzawa-Gerard, E. & Fontaine, Y. A. C. r. hedb. Séanc. Acad. Sci., Paris, 282, 97–100 (1976).
Pernollet, J. C., Garnier, J., Pierce, J. G. & Salesse, R. Biochim. biophys. Acta 446, 262–276 (1976).
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Marchelidon, J., Salesse, R., Garnier, J. et al. Zoological origin of gonadotropin subunits and association kinetics. Nature 281, 314–315 (1979). https://doi.org/10.1038/281314a0
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DOI: https://doi.org/10.1038/281314a0
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