Abstract
IMMUNE RESPONSES are regulated at least in part by a complex system of cellular interactions which result in the specific enhancement or suppression of the reaction to a given antigen. In many situations soluble ‘factors’ seem to be able to replace these cells, although whether they actually do so in vivo remains unknown. Specific suppressor factors have been demonstrated to influence a variety of humoral and cell-mediated immune responses. Specific helper factors which augment antibody production have been studied extensively1–3, but analogous factors active in cell-mediated immunity have not yet been documented. Soluble factors which enhance the generation of cytotoxicity have been reported by several workers4–8 but none of these has been demonstrated to be antigen specific. We report here the isolation of a helper factor which specifically enhances the generation of cytotoxic cells in a syngeneic mouse tumour system.
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KILBURN, D., TALBOT, F., TEH, HS. et al. A specific helper factor which enhances the cytotoxic response to a syngeneic tumour. Nature 277, 474–476 (1979). https://doi.org/10.1038/277474a0
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DOI: https://doi.org/10.1038/277474a0
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