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Interferon inhibits the release of plasminogen activator from SV3T3 cells

Nature volume 276, pages 828–829 (1978)Cite this article

Abstract

INTERFERON, as well as inducing an antiviral state, can modify certain other cell characteristics. For example, it has been shown to inhibit cell proliferation1–4 and release of C-type virus5,6, and to enhance the expression of H–2 antigens7,8 and the amount of glycoprotein on the cell surface9. These effects might be explained by decreased release of cell-surface components into the medium. Similarly, the expression of a glycoprotein on the cell surface has been related to the growth state of cells10, which can be explained in part by differential release11,12. We have followed up this suggestion by examining the effect of interferon on the release of plasminogen activator (PA) by a line of simian virus 40 transformed Swiss 3T3 (SV3T3) cells. Our results, reported here, indicate that interferon inhibits the release of PA by SV3T3 cells.

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Authors and Affiliations

  1. Department of Medicine, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02114

    EDWARD W. SCHRODER, IIH-NAN CHOU, SUSAN JAKEN & PAUL H. BLACK

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  1. EDWARD W. SCHRODER
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  3. SUSAN JAKEN
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  4. PAUL H. BLACK
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SCHRODER, E., CHOU, IN., JAKEN, S. et al. Interferon inhibits the release of plasminogen activator from SV3T3 cells. Nature 276, 828–829 (1978). https://doi.org/10.1038/276828a0

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