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Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity

Nature volume 276, pages 780–784 (1978)Cite this article

Abstract

The number of germline genes specifying the variable sequences of the V κ21 group of light chains was determined by saturation hybridisation analysis to be four to six. This gene multiplicity is considerably less than the total variability in the group, indicating that κ-chain diversity is generated by somatic mutations in both framework and complementarity-determining (hypervariable) regions.

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Authors and Affiliations

  1. Institute for Cancer Research, the Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111

    Oscar Valbuena, Kenneth B. Marcu, Martin Weigert & Robert P. Perry

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  1. Oscar Valbuena
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  2. Kenneth B. Marcu
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  4. Robert P. Perry
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Valbuena, O., Marcu, K., Weigert, M. et al. Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity. Nature 276, 780–784 (1978). https://doi.org/10.1038/276780a0

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