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The regulatory region of the biotin operon in Escherichia coli

Nature volume 276, pages 689–694 (1978)Cite this article

Abstract

It is proposed that the biotin anabolic operon in Escherichia coli is transcribed divergently from two partially overlapping face-to-face promoters. A mutation that increases transcription in vivo creates an additional promoter in vitro. The putative operator contains an imperfect palindromic sequence that partially overlaps the promoters. The regulatory and genetic implications of these findings are discussed.

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Authors and Affiliations

  1. Department of Chemistry, University of California, San Diego, La Jolla, California, 92093

    Anthony Otsuka & John Abelson

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  1. Anthony Otsuka
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  2. John Abelson
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Otsuka, A., Abelson, J. The regulatory region of the biotin operon in Escherichia coli. Nature 276, 689–694 (1978). https://doi.org/10.1038/276689a0

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