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Brain histamine receptors as targets for antidepressant drugs

Nature volume 272, pages 329–333 (1978)Cite this article

Abstract

A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.

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Authors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510

    Philip D. Kanof & Paul Greengard

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  1. Philip D. Kanof
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  2. Paul Greengard
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Kanof, P., Greengard, P. Brain histamine receptors as targets for antidepressant drugs. Nature 272, 329–333 (1978). https://doi.org/10.1038/272329a0

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