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CIDNP in tyrosyl protons of luliberin

Nature volume 271, pages 685–686 (1978)Cite this article

Abstract

WE report here on the possibility of extending CIDNP (chemically induced nuclear magnetic polarisation)-assisted NMR studies of the tyrosyl unit to medium sized peptides. Our previous studies indicate that, strong 1H nuclear polarisation may usually be obtained in phenols in the presence of dyes such as fluorescein or any of its halogenated derivatives, such as rose bengal, erythrosin B or eosin Y, and others excited to their triplet state1–4 The polarisation is due to the H atom transfer from the hydroxyl of the phenol ArOH to the triplet excited dye 3D, (a) ArOH+3D → ArO˙+DH˙ and back, (b) ArO˙+DH˙ → ArOH+D Steps (a) and (b) were shown to be chemically reversible, the nuclear polarisation resulting from the magnetic interactions in spin-correlated radical pairs ArO˙+DH˙.

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References

  1. Muszkat, K. A. & Weinstein, M. J. C. S. Chem. Commun. 143 (1975).

  2. Muszkat, K. A. & Weinstein, M. Forster Memorial Volume. Z. phys. Chem. 101, 105 (1976).

    Article  CAS  Google Scholar 

  3. Muszkat, K. A. & Weinstein, M. J. C. S. Perkin II, 1072 (1976).

  4. Muszkat, K. A. Chem. phys. Lett. 49, 583 (1977).

    Article  ADS  CAS  Google Scholar 

  5. Muszkat, K. A. J. C. S. Chem. Commun. 872 (1977); Muszkat, K. A. & Gilon, C. Biochem. biophys. Res. Commun. (in the press).

  6. Schally, A. V. et al. Biochem. biophys. Res. Commun. 43, 393 (1971).

    Article  CAS  Google Scholar 

  7. Ammoss, M. et al. Biochem. biophys. Res. Commun. 44, 205 (1971).

    Article  Google Scholar 

  8. Wessel, P. L. et al. J. Chem. Soc. Perkin II, 1691 (1973).

  9. Muus, L. T. (ed.) Chemically Induced Magnetic Polarization, Nato Advanerd Study Institutes Series 34, (Reidel, Dordrecht, 1977).

  10. Monahan, M. W., Amoss, M. S., Anderson, H. A. & Vale, W. Biochemistcy 12, 4616 (1973).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Structural Chemistry, The Weizmann Institute of Science, Rehovot, Israel

    K. A. MUSZKAT

  2. Department of Organic Chemistry, The Hebrew University, Jerusalem, Israel

    C. GILON

Authors
  1. K. A. MUSZKAT
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  2. C. GILON
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MUSZKAT, K., GILON, C. CIDNP in tyrosyl protons of luliberin. Nature 271, 685–686 (1978). https://doi.org/10.1038/271685a0

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  • DOI: https://doi.org/10.1038/271685a0

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