Abstract
ALTHOUGH little is known about the biochemistry of the formation of sister chromatid exchanges (SCEs), it has been suggested1–5 that they reflect some aspect of cellular DNA repair. Because agents that promote SCE formation (for example, refs 2, 3 and 6–9) also induce infectious virus from certain SV40-transformed hamster cell lines10,11 and because evidence suggests that virus induction involves DNA repair12,13, we have investigated a possible correlation between virus induction and SCE formation. We tested both events in the same cells in identical conditions. Parallel dose–response curves for both SCE formation and induction of infectious SV40 virus were observed with two alkylating agents, mitomycin C and ethyl methane sulphonate (EMS), which required effective concentrations differing by a factor of 10,000.
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KAPLAN, J., ZAMANSKY, G., BLACK, P. et al. Parallel induction of sister chromatid exchanges and infectious virus from SV40-transformed cells by alkylating agents. Nature 271, 662–663 (1978). https://doi.org/10.1038/271662a0
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DOI: https://doi.org/10.1038/271662a0
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