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Expression of MuLV GP71-like antigen in normal mouse spleen cells induced by antigenic stimulation

Abstract

ALL mouse strains investigated possess cellular DNA sequences which are homologous to the genomes of endogenous C-type particles1. Also, major envelope glycoproteins of the oncoviruses2, such as GP71, are found on the surface of normal cells and they display a considerable polymorphism. An antigen serologically indistinguishable from AKR murine leukaemia virus (MuLV) GP71 is present in normal bone marrow cells of all mouse strains investigated but not in normal spleen cells3. Allogeneic4 and mitogenic stimulation5,6 of spleen cells have been reported to result in C-type particle synthesis in some but not all mouse strains. We report here that both T and B lymphocytes of mice express a GP71-like antigen on their surfaces if antigenically stimulated.

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WECKER, E., SCHIMPL, A. & HÜNIG, T. Expression of MuLV GP71-like antigen in normal mouse spleen cells induced by antigenic stimulation. Nature 269, 598–600 (1977). https://doi.org/10.1038/269598a0

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