Abstract
INDIRECT evidence suggests that Ca2+ is the mediator of the effects of acetylcholine and cholecystokinin-pancreozymin in pancreatic acinar cells. Sustained stimulation-evoked acinar fluid and enzyme secretion depends on extracellular Ca2+ (refs 1,2), stimulation causes uptake of 45Ca2+ from the extracellular fluid3 as well as release of 45Ca2+ from prelabelled glands with a dose–response curve very similar to stimulation-evoked membrane depolarisation and enzyme secretion4 and the Ca2+ ionophore A23187 induces enzyme secretion5 and membrane depolarisation6. We have examined directly the bioelectrical effects of iontophoretic application of Ca2+ from intracellular microelectrodes in a mammalian gland cell preparation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Petersen, O. H. & Ueda, N. J. Physiol., Lond. 263, 223–224P (1976).
Petersen, O. H. & Ueda, N. J. Physiol., Lond. 254, 583–606 (1976).
Kondo, S. & Schulz, I. Biochim. biophys. Acta 419, 76–92 (1976).
Matthews, E. K., Petersen, O. H. & Williams, J. A. J. Physiol., Lond. 234, 689–701 (1973).
Selinger, Z., Eimerl, S., Savion, N. & Schramm, M. in Secretory Mechanisms of Exocrine Glands (eds Thorn, N. A. & Petersen, O. H.) 68–87 (Munksgaard, Copenhagen, 1974).
Poulsen, J. H. & Williams, J. A. J. Physiol., Lond. 264, 223–239 (1977).
Iwatsuki, N. & Petersen, O. H. Nature 263, 784–786 (1976).
Kusano, K., Miledi, R. & Stinnakre, J. Proc. R. Soc. Lond. B 189, 49–56 (1975).
Zimmerman, U., Pilwat, G., Holzaptel, C. & Rosenheck, K. J. memb. Biol. 30, 135–152 (1976).
Davison, J. S. & Ueda, N. J. Physiol., Lond. 266, 39–40P (1977).
Rose, B. & Loewenstein, W. R. Nature 254, 250–252 (1975).
Baker, P. F., Hodgkin, A. L. & Ridgeway, E. B. J. Physiol., Lond. 218, 709–755 (1971).
Nishiyama, A. & Petersen, O. H. J. Physiol., Lond. 238, 145–158 (1974).
Petersen, O. H. & Ueda, N. in Calcium Transport in Contraction and Secretion (eds Carafoli, E., Clementi, F., Drabikowsky, W. & Margreth, A.) 147–156 (North-Holland, Amsterdam, 1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
IWATSUKI, N., PETERSEN, O. Acetylcholine-like effects of intracellular calcium application in pancreatic acinar cells. Nature 268, 147–149 (1977). https://doi.org/10.1038/268147a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/268147a0
This article is cited by
-
An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
Nature Communications (2016)
-
The role of gap junction membrane channels in secretion and hormonal action
Journal of Bioenergetics and Biomembranes (1996)
-
Intracellular Ca2+ in pancreatic acinar cells: Regulation and role in stimulation of enzyme secretion
Bioscience Reports (1987)
-
Electrogenic calcium transport in plasma membrane of rat pancreatic acinar cells
The Journal of Membrane Biology (1985)
-
Effects of divalent cations on acetylcholine-evoked membrane potential in the ionophore A23187 treated mouse pancreas
Pfl�gers Archiv European Journal of Physiology (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
