Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Influence of multiple syngeneic foetal heart grafting on individual graft survival

Nature volume 264, pages 558–560 (1976)Cite this article

Abstract

THE factors which influence many developmental phenomena are poorly understood. One would like to know, for example, how it happens that an organism only develops one heart. A possible clue to this particular question arose inadvertently from an immunological tolerance assay involving inter-strain grafting of murine foetal hearts into adult ear pouches1. We noticed amongst the control syngeneic grafts that whereas single heart grafts had a high long-term survival rate, grafting two hearts into a single animal seemed to considerably reduce the individual graft survival rate. The experiments reported here extensively document this observation using different strains and different grafting sites, as well as control grafts for specificity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Diener, E., and Jirsch, D., Med. Clin. N. Amer., 56, 453–464 (1972).

    Article  CAS  Google Scholar 

  2. Metcalf, D., Transplantation, 2, 387–392 (1964).

    Google Scholar 

  3. Metcalf, D., and Moore, M. S., Haemopoietic Cells, 216 (North-Holland, Amsterdam and London, 1971).

    Google Scholar 

  4. Metcalf, D., Austr. J. exp. Biol. Med., 41, 437–448 (1963).

    Article  Google Scholar 

  5. Tachikowa, T., Nagasaki Igakkai Zasshi, 38, 98–103 (1963).

    Google Scholar 

  6. Elders, M., Parkam, B., and Hughes, E., J. exp. Med., 127, 649–659 (1968).

    Article  CAS  Google Scholar 

  7. Osoba, D., Science, 147, 298–299 (1965).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Transplantation Unit and Department of Immunology, Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7

    THOMAS G. WEGMANN & WILMA MELNYCHUK

Authors
  1. THOMAS G. WEGMANN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. WILMA MELNYCHUK
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WEGMANN, T., MELNYCHUK, W. Influence of multiple syngeneic foetal heart grafting on individual graft survival. Nature 264, 558–560 (1976). https://doi.org/10.1038/264558a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/264558a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing