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A human chromosomal determinant for susceptibility to herpes simplex virus

Nature volume 264, pages 556–558 (1976)Cite this article

Abstract

THE susceptibility of mammalian cells to virus infection has been studied in many virus–host systems. In certain instances1–6, the comparison of cells which do not permit productive infection with those that do has made it possible to identify the host factors which allow entry of the virus and support its subsequent growth. In the case of poliovirus the use of somatic cell hybrids between permissive and non-permissive cells has led to the assignment to human chromosome 19 of a gene coding for virus susceptibility7. Although cells from a wide variety of organisms, including many rodents and man, are susceptible to lytic infection by herpes simplex virus type 1 (HSV-1) resistance to HSV-1 infection has been reported in certain Chinese hamster cell lines8–10, in dog kidney cells11, and in a line of rat cells12. In these cell lines HSV-1 is either non-infectious or exhibits virus titres several orders of magnitude lower than in Syrian hamster or rabbit cells. The cellular factors involved in this resistance to infection and in the genetic control of susceptibility to HSV-1 have not yet been identified.

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References

  1. Hughes, R. C., and Mautner, V., in Membrane Mediated Information, 1 (edit. by Kent, P. W.), 104–125 (MTP Press, Lancaster, 1973).

    Google Scholar 

  2. Baum, S. G., and Fox, R. I., Cold Spring Harb. Symp. quant. Biol., 39, 567–578 (1974).

    Article  Google Scholar 

  3. Doerfler, W., Virology, 38, 587–606 (1969).

    Article  CAS  Google Scholar 

  4. Temin, H., Adv. Cancer Res., 19, 74–77 (1974).

    Google Scholar 

  5. Khoury, G., Byrne, J. C., and Martin, M. A., Proc. natn. Acad. Sci. U.S.A., 69, 1925–1928 (1972).

    Article  ADS  CAS  Google Scholar 

  6. Wang, R., Pollack, R., Kusano, T., and Green, H., J. Virol., 5, 677–681 (1970).

    Article  CAS  Google Scholar 

  7. Miller, D. A., et al., Cell, 1, 167–173 (1974).

    Article  Google Scholar 

  8. Hampar, B., and Ellison, S. A., Nature, 192, 145–147 (1961).

    Article  ADS  CAS  Google Scholar 

  9. Rapp, F., and Hsu, T. C., Virology, 25, 401–411 (1965).

    Article  CAS  Google Scholar 

  10. Stamfer, M., Baltimore, D., and Huang, A. S., J. Virol., 4, 154–161 (1969).

    Article  Google Scholar 

  11. Aurelian, L., and Roizman, B., Virology, 22, 252–401 (1964).

    Article  Google Scholar 

  12. Garfinkle, B., and McAuslan, B., Intervirology, 1, 362–375 (1973).

    Article  CAS  Google Scholar 

  13. Hsu, T. C., and Zenzes, M. T., J. natn. Cancer Inst., 32, 857–869 (1964).

    CAS  Google Scholar 

  14. Brown, S. M., Ritchie, D. A., and Subak-Sharpe, J. H., J. gen. Virol., 18, 329–346 (1973).

    Article  CAS  Google Scholar 

  15. Stoker, M., and McPherson, I., Nature, 203, 1355–1357 (1964).

    Article  ADS  CAS  Google Scholar 

  16. Littlefield, J. W., and Basilico, C., Nature, 211, 250–252 (1966).

    Article  ADS  CAS  Google Scholar 

  17. Giles, R. E., and Ruddle, F. H., in Tissue Culture Methods and Applications (edit. by Kruse, P. F., and Patterson, M. K.), 475–500 (Academic, New York, 1973).

    Book  Google Scholar 

  18. Littlefield, J. W., Science, 145, 709–710 (1964).

    Article  ADS  CAS  Google Scholar 

  19. Westerveld, A., Visser, R. P. L. S., Meera Khan, P., and Bootsma, D., Nature new Biol., 234, 20–24 (1971).

    Article  CAS  Google Scholar 

  20. Slack, C., Morgan, R. M., Carritt, B., Goldfarb, P. S. G., and Hooper, M. L., Expl Cell Res., 98, 1–4 (1976).

    Article  CAS  Google Scholar 

  21. Meera Khan, P., Archs Biochem. Biophys., 145, 470–483 (1971).

    Article  CAS  Google Scholar 

  22. Someren van, H., et al., Humangenetik, 25, 189–201 (1971).

    Google Scholar 

  23. Ruddle, F. H., and Creagan, R. P., A. Rev. Genetics, 9, 407–486 (1975).

    Article  CAS  Google Scholar 

  24. Miller, O. J., Aederdice, P. W., Miller, D. A., Breg, W. R., and Migeon, B. R., Science, 173, 244–245 (1971).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Cancer Research Campaign, Somatic Cell Genetics Group, Institutes of Genetics and Virology, Church Street, Glasgow, G11 5JR, UK

    BEN CARRITT & PETER GOLDFARB

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  1. BEN CARRITT
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  2. PETER GOLDFARB
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CARRITT, B., GOLDFARB, P. A human chromosomal determinant for susceptibility to herpes simplex virus. Nature 264, 556–558 (1976). https://doi.org/10.1038/264556a0

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