Abstract
A KNOWLEDGE of possible conformational states of double-helical nucleic acids is fundamental to an understanding of how they work1,2. Models for a series of conformations have been made on the basis of X-ray data3–5. Investigations of nucleic acids in solution point to the existence of a continuum of forms but do not make possible the quantitative determination of the conformational parameters. Here, theoretical investigation of the intramolecular interaction energy as a function of conformational parameters and a search for minimal energy regions in the space of these parameters become essential.
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KHUTORSKY, V., POLTEV, V. Conformations of double-helical nucleic acids. Nature 264, 483–484 (1976). https://doi.org/10.1038/264483a0
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DOI: https://doi.org/10.1038/264483a0
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