Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Impairment of luteinising-hormone release following oestrogen administration to hyperprolactinaemic ewes

Abstract

THE antigonadal role of prolactin during the post-partum period seems well established in many species1–3. But mechanisms by which prolactin may act are not yet known. There is some evidence that prolactin may exert its inhibitory function at the ovarian level4,5, but an eventual action on the hypothalamo–hypophysial axis cannot be excluded. Experiments described here have been designed to resolve this problem.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Tyson, J. E., Khojandi, M., Huth, J., Smith, B., and Thomas, P., Am. J. Obstet. Gynec., 121, 375–379 (1975).

    Article  CAS  Google Scholar 

  2. Lu, K. H., et al., J. Endocr., 68, 241–250 (1976).

    Article  CAS  Google Scholar 

  3. Kann, G., and Martinet, J., Nature, 257, 63–64 (1975).

    Article  ADS  CAS  Google Scholar 

  4. Zarate, A., Canales, E. S., Soria, J., Ruiz, F., and McGregor, C., Am. J. Obstet. Gynec., 112, 1130–1132 (1972).

    Article  CAS  Google Scholar 

  5. McNatty, K. P., Sawyers, R. S., and McNeilly, A. S., Nature, 250, 653–655 (1974).

    Article  ADS  CAS  Google Scholar 

  6. Kann, G., 5th Int. Congr. Endocr. Hamburg, Abstr., 611 (1976).

  7. Kann, G., C. r. hebd. Séance. Acad. Sci., Paris, 272, 2808–2811 (1971).

    CAS  Google Scholar 

  8. Kann, G., C. r. hebd. Séance. Acad. Sci., Paris, 272, 2934–2937 (1971).

    CAS  Google Scholar 

  9. Kann, G., Habert, R., and Denamur, R., C. r. hebd. Séance. Acad. Sci., Paris, 276, 1321–1324 (1973).

    CAS  Google Scholar 

  10. Thorner, M. O., McNeilly, A. S., Hagan, C., and Besser, G. H., Britt. med. J., 2, 419–422 (1974).

    Article  CAS  Google Scholar 

  11. Del-Pozo ., et al., J. clin. End. Met., 39, 18–26 (1974).

    Article  CAS  Google Scholar 

  12. Valcke, J. C., et al., Ann. Endocr., 35, 423–443 (1974).

    CAS  PubMed  Google Scholar 

  13. Maneckjee, R., Srinath, B. R., and Mougdal, N. R., Nature, 262, 507–508 (1976).

    Article  ADS  CAS  Google Scholar 

  14. Glass, M. R., Shaw, R. W., Logan-Edwards, R., Butt, W. R., and London, D. R., Int. Symp. Hvpoth. Endocr. Functions, Québec Abstract 21 (1975).

  15. Aono, T., Miyake, A., Shioji, T., Kinugasa, T., Onishi, T., and Kurachi, K., J. clin. End. Met., 42, 696–702 (1976).

    Article  CAS  Google Scholar 

  16. Yen, S. S. G., Siler, T. M., Van Den Berg, C., and Ehara, Y., Adv. Biosci., 15, 163–179 (1975).

    CAS  PubMed  Google Scholar 

  17. Fink, G., Aiyer, M. G., Jamieson, M. G., and Chiappa, S. A., in Hypothalannc Hormones, (edit. by Motta. M., Crosignani. P. G., and Martini. L.), 139–160 (1975).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

KANN, G., MARTINET, J. & SCHIRAR, A. Impairment of luteinising-hormone release following oestrogen administration to hyperprolactinaemic ewes. Nature 264, 465–466 (1976). https://doi.org/10.1038/264465a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/264465a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing