Abstract
THE arcuate nucleus (ARC) of the mammalian hypo-thalamus is thought to regulate tonic luteinising hormone (LH) secretion from the anterior pituitary1. But the immunohistochemical demonstration of luteinising hormone releasing factor (LHRF) in nerve fibres but not cell bodies of the ARC2,3 and the marked reduction in LHRF content after hypothalamic deafferentation4, suggest that the ARC is not a centre for LHRF synthesis. To clarify this issue we have used monosodium glutamate, a neurotoxin which when administered in a low dose to young animals selectively destroys ARC neurones While leaving intact axons passing through5–7. If the ARC perikarya synthesise LHRF, a marked reduction in the immunohistochemical staining and content of hypothalamic LHRF should be evident in glutamate-lesioned animals. Because thyroid function is unaffected by glutamate8, we examined brain tissue for thyrotropin releasing factor (TRF) content as a control for the LHRF studies.
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LECHAN, R., ALPERT, L. & JACKSON, I. Synthesis of luteinising hormone releasing factor and thyrotropin-releasing factor in glutamate-lesioned mice. Nature 264, 463–465 (1976). https://doi.org/10.1038/264463a0
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DOI: https://doi.org/10.1038/264463a0
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