Abstract
HUMAN adenovirus 2(Ad2), a DNA tumour virus that replicates in the nucleus of permissive human cells1,2, transforms non-permissive or semipermissive cultured rodent cells, but does not induce tumours in newborn hamsters (oncogenic group C). The constant functioning of protein product(s) from Ad2 ‘transforming gene(s)’ is probably responsible for the transformed phenotype, although this has not been proved. Identification and functional characterisation of ‘transforming protein(s)’ are important for the understanding of cell transformation and growth control. We describe here immunoprecipitation studies made with antisera against presumptive Ad2 ‘transforming protein(s)’, that identify two candidate transforming proteins of 53,000 (53k) and 15kdaltons.
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GILEAD, Z., JENG, YH., WOLD, W. et al. Immunological identification of two adenovirus 2-induced early proteins possibly involved in cell transformation. Nature 264, 263–266 (1976). https://doi.org/10.1038/264263a0
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DOI: https://doi.org/10.1038/264263a0
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