Abstract
THERE is increasing evidence that the turnover of the cholinergic receptor protein in developing or adult muscle fibres varies in the course of synaptogenesis or as a consequence of denervation1,2. Muscle activity is involved in this regulation3, but the mechanisms of the control processes and the chemical signals which mediate these effects remain largely unknown.
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References
Devreotes, P. N., and Fambrough, D. M., Cold Spring Harb. Symp. quant. Biol., 40, 237–251 (1976).
Brockes, J. P., Berg, D. K., and Hall, Z. W., Cold Spring Harb. Symp. quant. Biol., 40, 253–262 (1976).
Lømo, T., and Westgaard, R. H., Cold Spring Harb. Symp. quant. Biol., 40, 263–274 (1976).
Merlie, J. P., Sobel, A., Changeux, J. P., and Gros, F., Proc. natn. Acad. Sci. U.S.A., 72, 4028–4032 (1975).
Merlie, J. P., and Gros, F., Expl Cell. Res., 97, 406–412 (1976).
Klett, R. P., et al., J. biol. Chem., 248, 6841–6853 (1973).
O'Farrell, P. H., J. biol. Chem., 250, 4007–4021 (1975).
Devreotes, P. N., and Fambrough, D. M., J. cell Biol., 65, 335–358 (1975).
Berg, D. K., and Hall, Z. W., J. Physiol., Lond., 252, 771–789 (1975).
Chang, C. C., and Huang, M. C., Nature, 253, 643–644 (1975).
Brockes, J. P., and Hall, Z. W., Proc. natn. Acad. Sci. U.S.A., 72, 1368–1372 (1975).
Noll, H., in Techniques in Protein Biosynthesis (edit. by Campbell, P. N., and Sargent, J. R.), 101–179 (Academic, New York, 1969).
Vogel, Z., Sytkowski, A. J., and Niremberg, M. W., Proc. natn. Acad. Sci. U.S.A., 69, 3180–3184 (1972).
Dolly, J. O., and Barnard, E. A., FEBS Lett., 57, 267–271 (1975).
Ratner, D., J. molec. Biol., 88, 373–383 (1974).
Hogan, P. G., Marshall, J. M., and Hall, Z. W., Nature, 261, 328–330 (1976).
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MERLIE, J., CHANGEUX, J. & GROS, F. Acetylcholine receptor degradation measured by pulse chase labelling. Nature 264, 74–76 (1976). https://doi.org/10.1038/264074a0
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DOI: https://doi.org/10.1038/264074a0
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