Abstract
PROTECTION against dental caries in the rhesus monkey by immunisation has now been characterised with respect to the development of Streptococcus mutans1 and the corresponding antibodies2–4. One of the essential requirements for protection is the development of an optimum level of antibodies, at a critical time, before a large enough number of Strep. mutans has developed to initiate caries formation2. Antibody synthesis, amplification mechanisms and protection depend on cellular interactions associated with T and B lymphocytes and macrophages5. The aims of this investigation were to study the part that cell-mediated immune responses might play in the protective mechanism against dental caries. The incidence of caries and the growth of Strep. mutans in rhesus monkeys was studied sequentially and compared with the development of serum antibodies, in vitro DNA synthesis of antigen stimulated lymphocytes, leukocyte migration inhibition (LM1) and in vivo skin delayed hypersensitivity (DH) to Strep. mutans.
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LEHNER, T., CHALLACOMBE, S., WILTON, J. et al. Cellular and humoral immune responses in vaccination against dental caries in monkeys. Nature 264, 69–72 (1976). https://doi.org/10.1038/264069a0
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DOI: https://doi.org/10.1038/264069a0
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