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Stereospecificity of interaction of neuroleptic drugs with neurotransmitters and correlation with clinical potency

Nature volume 263, pages 338–341 (1976)Cite this article

Abstract

THE molecular mechanism responsible for the therapeutic activity of a drug is often suggested by the biochemical event which correlates best with clinical potency. Thus, if optical or geometrical isomers of a drug have markedly different clinical potencies, the most relevant biochemical effect should also exhibit isomeric specificity.

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Authors and Affiliations

  1. Departments of Pharmacology and Experimental Therapeutics, and Psychiatry and Behavioural Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205

    S. J. ENNA, J. P. BENNETT JR, D. R. BURT, I. CREESE & SOLOMON H. SNYDER

Authors
  1. S. J. ENNA
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  2. J. P. BENNETT JR
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  3. D. R. BURT
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  4. I. CREESE
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  5. SOLOMON H. SNYDER
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ENNA, S., BENNETT, J., BURT, D. et al. Stereospecificity of interaction of neuroleptic drugs with neurotransmitters and correlation with clinical potency. Nature 263, 338–341 (1976). https://doi.org/10.1038/263338a0

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