Abstract
INTACT erythrocyte membranes from patients with myotonic muscular dystrophy (MMD) have been shown by spin labelling (review of method in ref. 1) to have greater membrane surface fluidity than normal2,3. We have now evaluated the specificity of this phenomenon. We used erythrocytes from patients with MMD, and also from patients with Duchenne muscular dystrophy (DMD), as a model of dystrophy with no myotonia, and from patients with congenital myotonia (CM) as a model of myotonia without dystrophy.
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References
Spin Labelling—Theory and Applications (edit. by Berliner, L. J.) (Academic,New York, 1976).
Butterfield, D. A., Chesnut, D. B., Roses, A. D. and Appel, S. H., Proc. natn. Acad. Sci. U.S.A., 71, 909–913 (1974).
Butterfield, D. A., Roses, A. D., Cooper, M. L., Appel, S. H., and Chesnut, D. B., Biochemistry, 13, 5078–5082 (1974).
Lipicky, R. J., and Bryant, S. H., in New Developments in Electromyography and Clinical Neurophysiology, 1 (edit. by Desmedt, J. E.), 451–463 (Karger, Basel, 1973).
Roses, A. D., and Appel, S. H., Proc. natn. Acad. Sci. U.S.A., 70, 1855–1859 (1973).
Roses, A. D., and Appel, S. H., J. Membr. Biol., 20, 51–58 (1975).
Hull, K., and Roses, A. D., J. Physiol., Lond., 254, 169–181 (1975).
Miller, S. E., Roses, A. D., and Appel, S. H., Archs Neurol., 33, 172–174 (1976).
Butterfield, D. A., Whisnant, C. C., and Chesnut, D. B., Biochim. biophys. Acta, 426, 697–702 (1976).
Jost, P. C., Libertini, L. J., Herbert, V. C., and Griffith, O. H., J. molec. Biol. 59, 77–98 (1971).
Mason, R. P., Polnaszek, C. F., and Freed, J. H., J. phys. Chem., 78, 1324–1329 (1974).
Hubbell, W. L., and McConnell, H. M., J. Am. chem. Soc., 93, 314–326 (1971).
Brownlee, K. A., Statistical Theory and Methodology in Science and Engineering (Wiley, New York, 1960).
Weed, R. I., and LaCelle, P. L., in Red Cell Membrane Structure and Function (edit. by Greenwalt, T. J., and Jamieson, G. A.) (Lippincott, Philadelphia, 1969).
Roses, A. D., Appel, S. H., Butterfield, D. A., Miller, S. E., and Chesnut, D. B., Trans. Am. neurol. Ass., 100, 17–20 (1976).
Jackson, R. L., and Gotto, A. M., New Engl. J. Med., 290, 24–29 (1974).
Singer, S. J., A. Rev. Biochem., 43, 805–833 (1974).
Overath, P., and Trauble, H., Biochemistry, 12, 2625–2634 (1973).
Grisham, D. M., and Barnett, R. E., Biochemistry, 12, 2635–2637 (1973).
Eletr, S., Zakim, D., and Vessey, D. A., J. molec. Biol., 78, 351–362 (1973).
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BUTTERFIELD, D., CHESNUT, D., APPEL, S. et al. Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia. Nature 263, 159–161 (1976). https://doi.org/10.1038/263159a0
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DOI: https://doi.org/10.1038/263159a0
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