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A discontinuous relationship between the acetylcholine-activated channel conductance and temperature

Nature volume 263, pages 150–151 (1976)Cite this article

Abstract

SINCE the introduction of acetylcholine (ACh) ‘noise’ analysis1,2, it has been shown that several manipulations affect ACh-receptor molecular events3–5. The ACh receptor is an integral membrane protein and is therefore intimately associated with surrounding membrane lipids. We have begun experiments using embryonic chick muscle in culture to determine whether surrounding lipids affect the function of the ACh receptor. As a first step, we have analysed ACh current noise to determine the temperature dependence of the mean single channel conductance (g¯o) and open time (t¯0).

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Author information

Author notes

  1. YORAM LASS

    Present address: Department of Physiology and Pharmacology, Tel-Aviv University, Sackler Medical School, Tel-Aviv, Israel

Authors and Affiliations

  1. Department of Pharmacology, Harvard Medical School, Boston, Massachusetts, 02115

    YORAM LASS & GERALD D. FISCHBACH

Authors
  1. YORAM LASS
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  2. GERALD D. FISCHBACH
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LASS, Y., FISCHBACH, G. A discontinuous relationship between the acetylcholine-activated channel conductance and temperature. Nature 263, 150–151 (1976). https://doi.org/10.1038/263150a0

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