Abstract
WHEN the intracellular Ca2+ concentration of human red cells was increased by treatment of the cells with A23187, a divalent cation ionophore, they changed shape from discocyte to echinocyte1–3 and the 1,2-diacylglycerol content of their membranes was increased2–4. In these experiments it seemed that microvesicles budded off from the microvillus-like projections on the echinocytes2,3. We have now isolated the microvesicles and examined their composition and structure.
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References
White, J. G., Am. J. Path., 77, 507–518 (1974).
Allan, D., and Michell, R. H., Biochem. Soc. Trans., 3, 751–752 (1975).
Allan, D., and Michell, R. H., Nature, 258, 348–349 (1975).
Allan, D., Watts, R., and Michell, R. M., Biochem. J., 156, 225–232 (1976).
Billah, M. M., Coleman, R., Finean, J. B., and Michell, R. H., Biochim. biophys. Acta. (in the press).
Steck, T. L., J. molec. Biol., 66, 295–305 (1972).
Ahkong, Q. F., Fisher, D., Tampion, W., and Lucy, J. A., Biochem. J., 136, 147–155 (1973).
De Boer, E., and Loyter, A., FEBS Lett., 15, 325–327 (1971).
Allan, D., Low, M. G., Finean, J. B., and Michell, R. H., Biochim. biophys. Acta, 413, 308–316 (1975).
Maggio, B., and Lucy, J. A., Biochem. J., 149, 597–608 (1975).
Ahkong, Q. F., Tampion, W., and Lucy, J. A., Nature, 256, 208–209 (1975).
Ahkong, Q. F., Fisher, D., Tampion, W., and Lucy, J. A., Nature, 253, 194–195 (1975).
Steck, T. L., J. Cell Biol., 62, 1–19 (1974).
Tilney, L. G., and Detmers, P., J. Cell Biol., 66, 508–520 (1975).
Parkes, J. G., and Fox, C. F., Biochemistry, 14, 3725–3729 (1975).
Westerman, M. P., Pierce, L. E., and Jensen, W. N., J. lab. clin. Med., 62, 394–400 (1963).
Reed, C. F., and Swisher, S. N., J. clin. Invest., 45, 777–781 (1966).
Brown, H. H., Zlatkis, A., Zak, B., and Boyle, A. J., Analyt. Chem., 26, 397–399 (1954).
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ALLAN, D., BILLAH, M., FINEAN, J. et al. Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]. Nature 261, 58–60 (1976). https://doi.org/10.1038/261058a0
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DOI: https://doi.org/10.1038/261058a0
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