Abstract
IN spite of widespread use of lithium (Li) in psychiatry, the mechanism underlying its antimanic action is poorly understood. Studies of the effects of Li on spontaneous and drug-induced behavioural activity have yielded conflicting results1–8. Electrical self-stimulation of the brain (SS) may be a promising alternative approach to such studies. This behaviour is believed to be mediated by catecholamines (reviewed in ref. 9), which have also been implicated in the action of Li10–14. Investigations of the effects of Li on SS have been restricted to a small range of doses and to SS in lateral hypothalamus, and the results have not been consistent15,16. We have now used a wider range of doses to investigate the effects of acute and chronic Li on SS in the substantia nigra of rats.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Matussek, N., and Linsmayer, M., Life Sci., 7, 371–375 (1968).
D'Encarnacao, P. S., and Anderson, K., Dis. Nerv. Syst., 31, 494–496 (1970).
Cox, C., Harrison-Read, P. E., Steinberg, H., and Tomkiewicz, M., Nature, 232, 336–338 (1971).
Johnson, F. N., and Wormington, S., Nature, 235, 159–160 (1972).
U'Prichard, D. C., and Stein, H., Br. J. Pharmac., 44, 349–350P (1972).
Smith, D. F., and Smith, H. B., Psychopharmacologia, 30, 83–88 (1973).
Poitou, P., Boulu, R., and Bohoun, C., Experientia, 31, 99–101 (1975).
Segal, D. S., Callaghan, M., and Mandell, A. J., Nature, 254, 58–59 (1975).
German, D. C., and Bowden, D. M., Brain Res., 73, 381–419 (1974).
Corrodi, H., Fuxe, K., and Schou, M., Life Sci., 8, 643–651 (1969).
Katz, R. I., and Kopin, I. J., Biochem. Pharmac., 18, 1935–1939 (1969).
Greenspan, K., Aronoff, M. S., and Bogdanski, D. F., Pharmacology, 3, 129–136 (1970).
Friedman, E., and Gershon, S., Nature, 243, 520–521 (1973).
Schildkraut, J. J., in Lithium: Its Role in Psychiatric Research and Treatment (edit. by Gershon, S., and Shopsin, B.), 51–73 (Plenum, New York, 1973).
Ramsey, T. A., Mendels, J., Hamilton, C., and Frazer, A., Life Sci., 11, 773–779 (1972).
Pick-Cassens, G., and Mills, A. W., Psychopharmacologia, 30, 283–290 (1973).
Liebman, J. M., and Segal, D. S., Behav. Biol. (in the press).
Konig, J. F. R., and Klippel, R. A., in The Rat Brain (Krieger, Huntington, New York, 1967).
Schou, M., Acta pharmac. tox., 15, 70–84 (1958).
Stein, L., Fedn Proc., 23, 836–850 (1964).
Lorens, S. A., and Mitchell, C. L., Psychopharmacologia, 32, 271–277 (1973).
Liebman, J. M., and Butcher, L. L., Naunyn-Schmied. Arch. Pharmac., 284, 167–194 (1974).
Ayhan, I. H., and Randrup, A., Psychopharmacologia, 29, 317–328 (1973).
Villarreal, J. E., Guzman, M., and Smith, C. B., J. Pharmac. exp. Ther., 187, 1–7 (1973).
Tomkiewicz, M., and Steinberg, H., Nature, 252, 227–229 (1974).
Jensen, J., Acta pharmac. tox., 35, 395–402 (1974).
Crow, T. J., Brain Res., 36, 265–273 (1972).
Phillips, A. G., and Fibiger, H. C., Science, 179, 575–577 (1973).
Belluzzi, J. D., Ritter, S., Wise, C. D., and Stein, L., Behav. Biol., 13, 103–111 (1975).
Ritter, S., and Stein, L., Brain Res., 81, 145–157 (1974).
Stolk, J. M., and Rech, R. H., J. Pharmac. exp. Ther., 158, 140–149 (1967).
Carlsson, A., in Amphetamine and Related Compounds (edit. by Costa, E., and Garattini, S.), 289–300 (Raven, New York, 1970).
Fuxe, K., and Ungerstedt, U., in Amphetamine and Related Compounds (edit. by Costa, E., and Garattini, S.), 257–288 (Raven, New York, 1970).
Franklin, K. B. J., and Herberg, L. J., Brain Res., 67, 429–437 (1974)
Chiueh, C. C., and Moore, K. E., J. Pharmac. exp. Ther., 192, 642–653 (1975).
Carroll, B. J., and Sharp, P. T., Science, 172, 1355–1357 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LIEBMAN, J., SEGAL, D. Lithium differentially antagonizes self-stimulation facilitated by morphine and (+)-amphetamine. Nature 260, 161–163 (1976). https://doi.org/10.1038/260161a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/260161a0
This article is cited by
-
Response-dependent effects of morphine on reinforcing lateral hypothalamic self-stimulation
Psychopharmacology (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.