Abstract
THERE have been several reports that malignant cells carry on their surface a higher density of negative fixed charges than normal cells1–3. But it has been argued that the differences in observed surface charge reflect differences in cell growth rate rather than malignancy per se4–6. It has been difficult to resolve this controversy because earlier studies involved comparison between different types of cells, or between cells from the same origin but grown in different culture conditions and at different times after seeding. Using a neuroblastoma cell line7, we have avoided these shortcomings and made electrophoretic measurements on cells which are homologous from the genetic viewpoint, and which are grown in the same culture tray and collected at the same time, but which exhibit different stages of morphological differentiation.
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ELUL, R., BRONS, J. & KRAVITZ, K. Surface charge modifications associated with proliferation and differentiation in neuroblastoma cultures. Nature 258, 616–617 (1975). https://doi.org/10.1038/258616a0
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DOI: https://doi.org/10.1038/258616a0
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