Abstract
GENETIC traits may be transferred to tissue cultured mammalian cells by interaction with viruses1,2, nucleic acids3,4, and cellular organelles such as metaphase chromosomes5–7, and by other cells3,8. Recent findings9 indicate that incubation of mouse spermatozoa with Chinese hamster bone marrow fibroblasts (CLM) results in uptake of sperm, morphological alterations, and, at a frequency of about 0.01%, subsequent mouse foetal antigen expression in the heterologous fibroblast progeny. To learn whether the efficiency of these processes can be enhanced, combinations of several species of sperm and target cells were studied in orienting experiments10.
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HIGGINS, P., BORENFREUND, E. & BENDICH, A. Appearance of foetal antigens in somatic cells after interaction with heterologous sperm. Nature 257, 488–489 (1975). https://doi.org/10.1038/257488a0
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DOI: https://doi.org/10.1038/257488a0
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