Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Structural homology of myosin alkali light chains, troponin C and carp calcium binding protein

Nature volume 252, pages 646–649 (1974)Cite this article

Abstract

Sequence comparison between the myosin alkali light chain, troponin C and carp calcium binding protein shows that the pattern of hydrophobic residues which forms the core of calcium binding protein is preserved in both troponin C and myosin alkali light chain. Strong structural similarities between the proteins are suggested. The role of gene duplication in the evolution of troponin C and myosin alkali light chain is discussed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kretsinger, R. H., Nature new Biol., 240, 85–88 (1972).

    Article  CAS  PubMed  Google Scholar 

  2. Kretsinger, R. H., and Nockolds, C. E., J. biol. Chem., 248, 3313–3326 (1973).

    CAS  PubMed  Google Scholar 

  3. Collins, J. H., Potter, J. D., Horn, M. J., Wilshire, G., and Jackman, N., FEBS Lett., 36, 268–272 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. Coffee, C. J., and Bradshaw, R. A., J. biol. Chem., 248, 3305–3312 (1973).

    CAS  PubMed  Google Scholar 

  5. Pechère, J-F., Capony, J-P., and Ryden, L., Eur. J. Biochem., 23, 421–428 (1971).

    Article  PubMed  Google Scholar 

  6. Collins, J. H., Biochem. biophys. Res. Commun., 58, 301–308 (1974).

    Article  CAS  PubMed  Google Scholar 

  7. Weeds, A. G., and Frank, G., Cold Spring Harb. Symp. quant. Biol., 37, 9–16 (1972).

    Article  Google Scholar 

  8. Weeds, A. G., Biochem. J., 105, 25C–27C (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Frank, G., and Weeds, A. G., Eur. J. Biochem., 44, 317–334 (1974).

    Article  CAS  PubMed  Google Scholar 

  10. Potter, J. D., and Gergely, J., Fedn Proc., 33, 1465 (1974).

    Google Scholar 

  11. McLachlan, A. D., Nature new Biol., 240, 83–85 (1972).

    Article  CAS  PubMed  Google Scholar 

  12. McLachlan, A. D., J. molec. Biol., 64, 417–437 (1972).

    Article  CAS  PubMed  Google Scholar 

  13. Weber, A., and Murray, J. M., Physiol. Rev., 53, 612–673 (1973).

    Article  CAS  PubMed  Google Scholar 

  14. Perutz, M. F., Nature, 228, 726–739 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Adman, E. T., Sieker, L. C., and Jensen, L. H., J. biol. Chem., 248, 3987–3996 (1973).

    CAS  PubMed  Google Scholar 

  16. Pechère, J-F., Capony, J-P., and Damaille, J., Systematic Zool., 22, 533–548 (1973).

    Article  Google Scholar 

  17. Lehky, P., Blum, H. E., Stein, E. A., and Fischer, E. H., Fedn Proc., 33, 1522 (1974).

    Google Scholar 

  18. Dreizen, P., and Richards, D. H., Cold Spring Harb. Symp. quant. Biol., 37, 29–45 (1972).

    Article  Google Scholar 

  19. Kim, H. D., and Mommaerts, W. F. H. M., Biochim. biophys. Acta, 245, 230–234 (1971).

    Article  CAS  PubMed  Google Scholar 

  20. Wagner, P. D., and Yount, R. C., Fedn Proc., 33, 1581 (1974).

    Google Scholar 

  21. Szent-Györgyi, A. G., Szentkiralyi, E. M., and Kendrick-Jones, J., J. molec. Biol., 74, 179–203 (1973).

    Article  PubMed  Google Scholar 

  22. Lehman, W., Kendrick-Jones, J., and Szent-Györgyi, A. G., Cold Spring Harb. Symp. quant. Biol., 37, 319–330 (1972).

    Article  Google Scholar 

  23. Haselgrove, J. C., thesis, Cambridge Univ. (1970).

  24. Huxley, H. E., Cold Spring Harb. Symp. quant. Biol., 37, 361–376 (1972).

    Article  Google Scholar 

  25. Werber, M. M., Szent-Györgyi, A. G., and Fasman, G. D., J. Mechanochem. Cell Motility, 2, 35–43 (1973).

    CAS  Google Scholar 

  26. Werber, M. M., Gaffin, S. L., and Oplatka, A., J. Mechanochem. Cell Motility, 1, 91–96 (1972).

    CAS  Google Scholar 

  27. Kendrick-Jones, J., Nature, 249, 631–634 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Tufty, R. M., and Kretsinger, R. H., Science (in the press).

Download references

Author information

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    A. G. Weeds & A. D. McLachlan

Authors
  1. A. G. Weeds
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. D. McLachlan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weeds, A., McLachlan, A. Structural homology of myosin alkali light chains, troponin C and carp calcium binding protein. Nature 252, 646–649 (1974). https://doi.org/10.1038/252646a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/252646a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing