Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Antigenic specificity of retinal pigment epithelium and non-immunological involvement in retinal dystrophy

Nature volume 252, pages 307–308 (1974)Cite this article

Abstract

ORGAN specific antigens have been demonstrated in the retina proper and particular attention has been paid to their relation to eye disease1–7. The antigenicity of the photoreceptors has also been demonstrated8 and its implication in the pathological process of retinal dystrophy in experimental animals and in man has been lately under evaluation9–10. In the case of the retinal pigment epithelium (RPE), however, no conclusive evidence of its antigenicity or immunological involvement in ocular disease has so far been produced. Nevertheless this layer fulfils an important physiological role11–13 and its primary involvement in retinal dystrophy has been emphasised14–17.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Wacker, W. B., and Lipton, M. M., Nature, 206, 253–254 (1965).

    Article  ADS  CAS  Google Scholar 

  2. Wacker, W. B., and Lipton, M. M., J. Immun., 101, 151–156 (1968).

    CAS  PubMed  Google Scholar 

  3. Wacker, W. B., and Lipton, M. M., J. Immun., 101, 157–165 (1968).

    CAS  PubMed  Google Scholar 

  4. Wacker, W. B., and Lipton, M. M., Int. Arch. Allergy appl. Immun., 41, 370–380 (1971).

    Article  CAS  Google Scholar 

  5. Schlaegel, T. F., Arch. Ophthal., 85, 624–635 (1971).

    Article  Google Scholar 

  6. Schillinger, G., and Homberg, J., Expl Eye Res., 14, 264–269 (1972).

    Article  CAS  Google Scholar 

  7. Tilgner, S., Meyer, W., Hempel, E., and Schröder, K. D., Expl Eye Res., 15, 71–73 (1973).

    Article  CAS  Google Scholar 

  8. Rahi, A. H. S., Br. J. Ophthal., 54, 441–444 (1970).

    Article  CAS  Google Scholar 

  9. Rahi, A. H. S., Lucas, D. R., and Waghe, M., Proc. Int. Symp. Immun. Immunopathol. Eye, Strasbourg, 1974. (S. Karger, Basel, in the press).

    Google Scholar 

  10. Char, D. H., Bergsma, D. R., Rabson, A. S., Albert, D. M., and Herberman, R. B., Invest. Ophthal., 13, 198–203 (1974).

    CAS  PubMed  Google Scholar 

  11. Bernstein, M. H., The Structure of the eye (edit. by Smelser, G. K.), 139–150 (Academic Press, New York and London, 1961).

    Google Scholar 

  12. Moyer, F. H., The Retina (edit. by Stratsma et al.), 1–30 (University of California Press, Los Angeles, 1969).

    Google Scholar 

  13. Young, R. W., and Bok, D., J. Cell Biol., 42, 392–403 (1969).

    Article  CAS  Google Scholar 

  14. Herron, W. L., Riegel, B. W., Myers, O. E., and Rubin, M. L., Invest. Ophthal., 8, 595–604 (1969).

    CAS  PubMed  Google Scholar 

  15. Bok, D., and Hall, M. O., Invest. Ophthal., 8, 649–650 (1969).

    Google Scholar 

  16. Herron, W. L., Riegel, B. W., and Rubin, M. L., Invest. Ophthal., 10, 54–63 (1971).

    PubMed  Google Scholar 

  17. Herron, W. L., Riegel, B. W., Brennan, E., and Rubin, M. L., Invest. Ophthal., 13, 87–94 (1974).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Institute of Ophthalmology, University of London, Judd Street, London, WC1H 9QS, UK

    F. REICH-D'ALMEIDA & A. H. S. RAHI

Authors
  1. F. REICH-D'ALMEIDA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. H. S. RAHI
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

REICH-D'ALMEIDA, F., RAHI, A. Antigenic specificity of retinal pigment epithelium and non-immunological involvement in retinal dystrophy. Nature 252, 307–308 (1974). https://doi.org/10.1038/252307a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/252307a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing