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Specific binding of growth hormone to thymocytes

Nature volume 252, pages 255–257 (1974)Cite this article

Abstract

As well as its general trophic effect on lymphoid tissue1, growth hormone (STH) specifically increases the activity of thymocytes in a graft versus host reaction2 and their helper activity3. In vitro studies showed that STH alters the mitotic activity, RNA and protein metabolism of thymocytes4,5. At least for the effects obtained in vitro, it is assumed that STH binds to the thymocytes and thereby changes their physiological activity. The nature of this binding has not been studied. To learn about the characteristics of the surmised interaction, bovine STH (Nutritional Biochemicals, Cleveland, Ohio) and bovine prolactin (National Institutes of Health, lot NIH B4) were labelled with 125I and their binding to lymphoid cells was studied.

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Author notes

  1. STEFAN ARRENBRECHT

    Present address: Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel

Authors and Affiliations

  1. Medizinische Abteilung, Schweizerisches Forschungsinstitut, Davos, Switzerland

    STEFAN ARRENBRECHT

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  1. STEFAN ARRENBRECHT
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ARRENBRECHT, S. Specific binding of growth hormone to thymocytes. Nature 252, 255–257 (1974). https://doi.org/10.1038/252255a0

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