Abstract
STUDIES reported during the past 15 years have led to the widely accepted conclusion that polyene antibiotics function by binding with the sterol molecules in susceptible cells to cause permeability change and eventual death of the cell1–3. In recent reports4–6 based on liposomal model membrane studies, it has been suggested that susceptibility to polyene antibiotics is determined by organisation rather than by a single component of the membrane, namely sterol. Here, through study of polyene-resistant mutants, we further propose that, at least in some cases, permeability alteration may not be the specific critical event in the fungicidal action of polyene antibiotics.
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HSUCHEN, C., FEINGOLD, D. Two types of resistance to polyene antibiotics in Candida albicans. Nature 251, 656–659 (1974). https://doi.org/10.1038/251656a0
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DOI: https://doi.org/10.1038/251656a0
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