Abstract
WHILE we were looking for cell-mediated immunoreactions in patients with active chronic hepatitis (ACH), non-reproducible results with the leukocyte migration inhibition test1, using different preparations of liver antigen from human liver, led us to attempt to prepare a better defined antigen from human liver—already proposed2 for this test system. Besides a liver specific protein as previously described11, our preparation yielded a soluble fraction, which inhibited the peripheral leukocytes of patients with active chronic hepatitis, but also inhibited the leukocyte migration of controls. The migration inhibition in these cases was therefore not due to a cell-mediated immune reaction against liver antigen, but was caused by a previously unknown inhibiting substance, extracted from human liver. Here we report some properties of this inhibitor.
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SCHUMACHER, K., MAERKER-ALZER, G. & WEHMER, U. A lymphocyte-inhibiting factor isolated from normal human liver. Nature 251, 655–656 (1974). https://doi.org/10.1038/251655a0
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DOI: https://doi.org/10.1038/251655a0
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