Abstract
TUMOUR-specific transplantation antigens (TSTA), have been detected on a wide range of experimental tumour cells and elicit weak immunogenic activity. As a rule, little immune response of the host to autocthonous tumours or to implanted syngeneic tumours has been detected. Furthermore, immunological techniques, such as active immunisation, passive transfer of antibodies or adoptive transfer of immune lymphocytes, have not been entirely satisfactory. Attempts have also been made to increase the immunogenic properties of tumour cells by in vitro enzymatic treatments1 or in vitro coating of antigenic determinants on cancer cells2.
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NICOLIN, A., BINI, A., CORONETTI, E. et al. Cellular immune response to a drug-treated L5178Y lymphoma subline. Nature 251, 654–655 (1974). https://doi.org/10.1038/251654a0
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DOI: https://doi.org/10.1038/251654a0
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