Abstract
IMMUNOLOGICAL reactions depend for their completeness on at least two different populations of lymphocytes, one derived from the bone marrow and the other from the thymus (B and T cells). B lymphocytes, precursors of the antibody-forming cells of vertebrates, are recognised in vitro by two characteristic reactions: surface fluorescence with antisera to immunoglobulins1 and rosette formation with red cells sensitised with some components of complement2. Since the cells that show surface immunofluorescence are retained on columns of beads coated with antibodies to immunoglobulins3, surface fluorescence is generally interpreted to mean that immunoglobulins are present on the surface of B lymphocytes4.
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MERLER, E., GATIEN, J. & DE WILDE, G. Significance of immunofluorescent staining of lymphocytes with antisera to IgM immunoglobulins. Nature 251, 652–654 (1974). https://doi.org/10.1038/251652a0
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DOI: https://doi.org/10.1038/251652a0
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