Abstract
GRAFT-versus-host (GvH) disease is a complex syndrome initiated by the reaction of donor lymphoid cells against histocompatibility antigens of the host. Although newborn hybrid animals injected with parental-strain lymphoid cells develop fatal GvH disease, adult hybrid animals receiving weight-adjusted doses of such cells develop no clinically evident disease1,2. This resistance to GvH disease is agedependent and radiosensitive; resistance develops at 3–4 weeks of age and is abolished by sublethal total-body irradiation1. Immunologically specific suppression of GvH reactions has been achieved by immunisation of F1 hybrid host to produce antibody reactive with receptors on donor lymphoid cells for host antigens3,4.
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MCKEARN, T., HAMADA, Y., STUART, F. et al. Anti-receptor antibody and resistance to graft-versus-host disease. Nature 251, 648–650 (1974). https://doi.org/10.1038/251648a0
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DOI: https://doi.org/10.1038/251648a0
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