Abstract
THE rapid disappearance from circulation of human erythrocytes transfused to rats can be prevented if the animals are pretreated with ethyl palmitate (EP) and a cobra venom factor (CVF)1. The improvement in human erythrocyte survival in these animals is due to EP-induced impairment of reticuloendothelial function2 and to suppression of intravascular haemolysis through CVF inhibition of the third component of complement3. The halflife of normal human erythrocytes in the blood of untreated rats is less than 15 min, but is about 30 h in the EP and CVF treated rats4.
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CASTRO, O., FINCH, S. & OSBALDISTON, G. Sickle cell resistance to in vivo hypoxia. Nature 251, 620–621 (1974). https://doi.org/10.1038/251620a0
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DOI: https://doi.org/10.1038/251620a0
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