Abstract
HELMINTH parasites provide the most potent stimulus known for the biosynthesis of IgE. In every species which has been studied, infections with parasitic worms lead to the production of high levels of reaginic or IgE antibodies against parasite antigens1,2 and, in man, greatly elevated levels of total IgE occur in most individuals infected with any one of a variety of helminths including Ascaris lumbricoides3, Capillaria philipinensis4 and ancylostomes5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ogilvie, B. M., and Jones, V. E., Cellular and Humoral Mechanisms in Anaphylaxis and Allergy, 13–22 (Karger Basel, 1969).
Sadun, E. H., in Immunity to Animal Parasites (edit. by Soulsby, E. J. L.), 97–129 (Academic Press, 1972).
Johansson, S. G. O., Melbin, T., and Vahlquist, B., Lancet, i, 1118–1121 (1968).
Rosenberg, E. G., Whalen, G. E., Bennich, H., and Johansson, S. G. O., New Engl. Jl Med., 238, 1148–1149 (1970).
Bennich, H., and Johansson, S. G. O., Adv. Immun., 13, 1–55 (1971).
Orr, T. S.C., and Blair, A. M. J. N., Life Sci., 8, part III, 1073–1077 (1969).
Jarrett, E. E. E., Immunology, 22, 1099–1101 (1971).
Jarrett, E. E. E., and Stewart, D. C., Immunology, 23, 749–755 (1972).
Jarrett, E. E. E., and Ferguson, A., Nature, 250, 420–422 (1974).
Bazin, H., Beckers, A., Deckers, C., and Moriame, M., J. natn. Cancer Inst., 51, 1351–1361 (1973).
Bazin, H., Querinjean, P., Beckers, A., Heremans, J. P., and Dessy, F., Immunology, 26, 713–723 (1974).
Rowe, D. S., Bull. Wld Hlth Org., 40, 613–616 (1969).
Avrameas, S., and Ternynck, J., Immunochemistry, 6, 53–66 (1969).
Steinbuch, N., and Audran, R., Arch. Biochem. Biophys., 134, 279–284 (1969).
McConahey, P., and Dixon, F. J., Int. Arch. Allergy, 29, 185–189 (1969).
Jarrett, E. E. E., and Stewart, D. C., Immunology, 27, 365–381 (1974).
Ovary, Z., Immunological Methods (edit. by Ackroyd, J. F.), 259–283 (Blackwell, Oxford, 1964).
Jennings, F. W., Mulligan, W., and Urquhart, G. M., Exp. Parasit., 13, 367–373 (1963).
Jarrett, E. E. E., Jarrett, W. F. H., and Urquhart, G. M., Parasitol., 58, 625–639 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JARRETT, E., BAZIN, H. Elevation of total serum IgE in rats following helminth parasite infection. Nature 251, 613–614 (1974). https://doi.org/10.1038/251613a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/251613a0
This article is cited by
-
Antigenic cross-reactivity between Schistosoma mansoni and allergenic invertebrates putatively due to shared glycanic epitopes
Scientific Reports (2020)
-
Nickel oxide nanoparticles can recruit eosinophils in the lungs of rats by the direct release of intracellular eotaxin
Particle and Fibre Toxicology (2015)
-
The role of FcεRI expressed in dendritic cells and monocytes
Cellular and Molecular Life Sciences (2015)
-
IgE, allergies and helminth parasites: A new perspective on an old conundrum
Immunology & Cell Biology (1996)
-
Total and specific IgE in serum and cerebrospinal fluid of rats and guinea pigs infected withAngiostrongylus cantonensis
Parasitology Research (1989)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.