Abstract
LITTLE is known of retinal transmitter substances although acetylcholine, dopamine, 5-HT, γ-aminobutyric acid (GABA), gluitamate, and aspartate have all been put forward as candidates for such a role1–9. In other areas of the central nervous system (CNS), the preparation of isolated nerve-ending particles (synaptosomes) has been extremely valuable in studying central transmitter substances10–13. As far as we are aware, however, subcellular fractionation procedures have not previously been applied to the study of retinal transmitter substances.
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References
Lam, D. M. K., Proc. natn. Acad. Sci. U.S.A., 69, 1987–1991 (1972).
Nichols, C. W., and Koelle, G. B., J. comp. Neurol., 133, 1–15 (1968).
Kramer, S. G., Potts, A. M., and Mangnall, Y., Invest. Ophthal., 10, 617–624 (1971).
Ehinger, B., and Falck, B., Brain Res., 33, 157–172 (1971).
Ehinger, B., and Falck, B., Z. Zellforsch. mikrosk. Anat., 100, 364–375 (1969).
Straschill, M., and Perwein, J., Pflügers Arch. ges. Physiol., 312, 45–54 (1969).
Kuriyama, K. E., Sisken, B., Haber, B., and Roberts, E., Brain Res., 9, 165–168 (1968).
Graham, L. T., jun., Brain Res., 36, 476–479 (1972).
Ames, A., and Pollen, D. A., J. Neurophysiol., 32, 424–442 (1969).
Gray, E. G., and Whittaker, V. P., J. Anat., 96, 79–88 (1962).
De Robertis, E., De Iraldi, A. P., De Lores Arnaiz, G. R., and Salganicoff, L., J. Neurochem., 9, 23–35 (1962).
Whittaker, V. P., Prog. Biophys. molec. Biol., 15, 41–96 (1965).
Snyder, S. H., Young, A. B., Bennett, J. P., and Mulder, A. H., Fedn Proc., 32, 2039–2047 (1973).
Atterwill, C. K., and Neal, M. J., Br. J. Pharmac., 50, 449–450P (1974).
Atterwill, C. K., and Neal, M. J., Br. J. Pharmac., 48, 355–356P (1973).
Dowling, J. E., Invest. Ophthal., 9, 655–680 (1970).
Gray, E. G., and Pease, H. L., Brain Res., 35, 1–15 (1971).
Lemkey-Johnston, N., and Larramendi, L. M. H., J. Cell Biol., 39, 80a (1968).
Trifonov, J. A., Biofizika, 13, 809–817 (1968).
Toyoda, J., Nasaki, H., and Tomita, T., Vision Res., 9, 453–463 (1969).
Dowling, J. E., and Ripps, H., Nature, 242, 101–103 (1973).
Fonnum, F., Biochem. J., 106, 401–412 (1968).
Neal, M. J., and Iversen, L. L., J. Neurochem., 16, 1245–1252 (1969).
Saito, K., Barber, R., Wu, J.-T., Matsuda, T., Roberts, E., and Vaughn, J. C., Proc. natn. Acad. Sci. U.S.A., 71, 269–273 (1974).
Iversen, L. L., and Bloom, F. E., Brain Res., 41, 131–143 (1972).
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NEAL, M., ATTERWILL, C. Isolation of photoreceptor and conventional nerve terminals by subcellular fractionation of rabbit retina. Nature 251, 331–333 (1974). https://doi.org/10.1038/251331a0
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DOI: https://doi.org/10.1038/251331a0
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