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Isolation of photoreceptor and conventional nerve terminals by subcellular fractionation of rabbit retina

Abstract

LITTLE is known of retinal transmitter substances although acetylcholine, dopamine, 5-HT, γ-aminobutyric acid (GABA), gluitamate, and aspartate have all been put forward as candidates for such a role1–9. In other areas of the central nervous system (CNS), the preparation of isolated nerve-ending particles (synaptosomes) has been extremely valuable in studying central transmitter substances10–13. As far as we are aware, however, subcellular fractionation procedures have not previously been applied to the study of retinal transmitter substances.

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NEAL, M., ATTERWILL, C. Isolation of photoreceptor and conventional nerve terminals by subcellular fractionation of rabbit retina. Nature 251, 331–333 (1974). https://doi.org/10.1038/251331a0

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