Abstract
EXPERIMENTAL allergic neuritis (EAN) is induced by the injection of peripheral nerve myelin and Freund's complete adjuvant into experimental animals1. It is characterised clinically by an acute motor paralysis accompanied by ataxia, both of which vary in severity from a mild to an extremely severe form. Histology shows focal areas of demyelination and mononuclear cell infiltration confined to the peripheral nervous system (PNS). It is one of a group of autoimmune delayed hypersensitivity conditions which are specific for target tissue but not for species. Experimental allergic encephalitis (EAE) is also an experimentally induced paralysing disease, but in this case the pathology is confined to the central nervous system (CNS). It is induced by injection of myelin of central nervous system origin in Freund's adjuvant. The observation that myelin from the CNS produced lesions confined to the CNS, whereas that from peripheral nerves produced lesions in the PNS has now been explained on the basis of biochemical differences between myelin from the two sites of origin2,3.
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CRAWFORD, C., EVANS, D. & EVANS, E. Experimental allergic neuritis induced by sensory nerve myelin may provide a model for nonlepromatous leprosy. Nature 251, 223–225 (1974). https://doi.org/10.1038/251223a0
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DOI: https://doi.org/10.1038/251223a0
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