Abstract
THE main route of passive ion permeability in gallbladder and other ‘leaky’ epithelia is through the so-called ‘tight’ junctions between cells, not through the cells themselves1. I report here that the protonated form of the organic base 2,4,6-triamino-pyrimidine (TAP), reversibly and specifically blocks cation permeation across this tight junction route in frog gallbladder and several other leaky epithelia. Since in these epithelia the tight junction permeability is mainly (or even completely) cationic, in principle on addition of TAP a low resistance, leaky epithelium can become a high resistance epithelium.
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MORENO, J. Blockage of cation permeability across the tight junctions of gallbladder and other leaky epithelia. Nature 251, 150–151 (1974). https://doi.org/10.1038/251150a0
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DOI: https://doi.org/10.1038/251150a0
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