Abstract
Studies of the trp mRNA made by Salmonella typhimurium strains carrying trpOA and trpOAB multisite mutations have shown that these are deletions. They do not extend into the trp promoter (trpP1) as shown by their ability to recombine with trpP4 mutation. Thus the trp operator (trpO) and the trp promoter are seperable and arranged in the order P1-O-A.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Callahan III, R., Blume, A. J., and Balbinder, E., J. molec. Biol., 51, 709, (1970).
Jordan, E., Saedler, H., and Starlinger, P., Molec. gen. Genet., 102, 353 (1968).
Shapiro, J. A., J. molec. Biol., 40, 93 (1969).
Balbinder, E., Blume, A. J., Weber, A., and Tamaki, H., J. Bact., 95, 2217 (1968).
La Scolea, L. J., and Balbinder, E., J. Bact., 112, 877 (1972).
Balbinder, E. Callahan III, R., McCann, P. P., Cordaro, J. C., Weber, A. R., Smith, A. M., and Angelosanto, F., Genetics, 66, 31 (1970).
Denney, R. M., and Yanofsky, C., J. molec. Biol., 64, 319 (1972).
Imamoto, F., and Yanofsky, C., J. molec. Biol., 28, 1 (1967).
Imamoto, F., Morikawa, N., and Sato, K., J. molec. Biol., 13, 169 (1965).
Ito, J., and Crawford, I. P., Genetics, 52, 1303 (1965).
Blume, A. J., and Balbinder, E., Genetics, 53, 577 (1966).
Rose, J. K., Mosteller, R. D., and Yanofsky, C., J. molec. Biol., 51, 541 (1970).
Hiraga, S., and Yanofsky, C., Nature new Biol., 237, 47 (1972).
Cordaro, J. C., and Balbinder, E., Genetics, 67, 151 (1971).
Demerec, M. E., Adelberg, E. A., Clark, A. J., and Hartman, P. E., Genetics, 54, 61 (1966).
Vogel, H. J., and Bonner, D. M., J. biol. Chem., 218, 97 (1956).
Okamoto, K., Sugino, Y., and Nomura, M., J. molec. Biol., 5, 527 (1962).
Morse, D. A., and Yanofsky, C., J. molec. Biol., 41, 317 (1969).
Gillespie, D., and Spiegelman, S., J. molec. Biol., 12, 829 (1965).
Smith, O. H., and Yanofsky, C., in Methods in enzymology (edit. by Colowick, S. P., and Kaplan, N. O.) 5, 794 (Academic Press, New York, 1962).
Bauerle, R. H., and Margolin, P., Proc. natn. Acad. Sci. U.S.A., 56, 111 (1966).
Blume, A. J., Weber, A., and Balbinder, E., J. Bact., 95, 2230 (1968).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265 (1951).
Smith, H. O., and Levine, M., Virology, 31, 207 (1967).
Benzinger, R., and Hartman, P. E., Virology, 18, 614 (1962).
Grieshaber, M., and Bauerle, R. H., Nature new biol., 236, 232 (1972).
Margolin, P., and Bauerle, R. H., Cold Spring Harbor Symp. quant. Biol., 31, 311 (1966).
Leive, L., Biochem. biophys. Res. Commun., 18, 13 (1965).
Mosteller, R. D., and Yanofsky, C., J. molec. Biol., 48, 525 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Aono, H., Angelosanto, F. & Balbinder, E. Operator and promoter are separate in the tryptophan operon in Salmonella typhimurium. Nature 251, 119–123 (1974). https://doi.org/10.1038/251119a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/251119a0
This article is cited by
-
A mutation to 5-methyltryptophan dependence in the trp operon of Salmonella typhimurium
Molecular and General Genetics MGG (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.