Abstract
THE effects of parent prostaglandins (PG) on bronchial muscle in vitro1–3 and in vivo4,5 have been characterised, but the pharmacological properties of their metabolites are less well defined. The lung is an important site of PG metabolism and a better understanding of the effects of the various metabolites is necessary since PGs are now recognised as compounds released in asthma. Modification of PG metabolism itself could be responsible for the aetiology of the asthmatic bronchospasm, particularly since asthmatic subjects have been shown to be considerably more sensitive to inhaled PGF2α than the normal population6. We have shown that 15-keto PGF2α possesses very potent bronchoconstrictor activity and is probably important in asthma.
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DAWSON, W., LEWIS, R., MCMAHON, R. et al. Potent bronchoconstrictor activity of 15-keto prostaglandin F2α. Nature 250, 331–332 (1974). https://doi.org/10.1038/250331a0
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DOI: https://doi.org/10.1038/250331a0
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