Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Immunosuppression detected in pregnant mice by rosette inhibition test

Nature volume 249, pages 459–460 (1974)Cite this article

Abstract

ATTENTION has recently been drawn to the immunological mechanisms concerned in the nonrecognition of the antigenic status of the foetus during uterine life. Several workers1–3 have demonstrated that lymphocyte transformation is suppressed during pregnancy. As the rosette inhibition test4 has been used to show that the lymphocyte activity in vivo is modified by immunosuppressive therapy following trasnplantation5, it suggests that this technique could also be used to investigate possible immunosuppression during pregnancy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Purtilo, D. T., Hallgren, H. M., and Yunis, E. J., Lancet, i, 769 (1972).

    Article  Google Scholar 

  2. Finn, R., St. Hill, C. A., Govan, A. J., Ralfs, I. G., Gurney, F. J., and Denye, V., Br. med. J., 3, 150 (1972).

    Article  CAS  Google Scholar 

  3. Contractor, S. F., and Davies, H., Nature new Biol., 243, 284 (1973).

    Article  CAS  Google Scholar 

  4. Bach, J. F., Dormont, J., Dardenne, M., and Balner, H., Transplantation, 8, 265 (1969).

    Article  CAS  Google Scholar 

  5. Munro, A., Bewick, M., Manuel, L., Cameron, J. S., Ellis, F. G., Boulton-Jones, M., and Ogg, C. S., Br. med. J., 3, 271 (1971).

    Article  CAS  Google Scholar 

  6. Morton, H., Hegh, V., and Clunie, G. J. A., Clin. exp. Immun., 13, 595 (1973).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Queensland at the Princess Alexandra Hospital, Brisbane, 4102, Australia

    HALLE MORTON, VALERIE HEGH & G. J. A. CLUNIE

Authors
  1. HALLE MORTON
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. VALERIE HEGH
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. J. A. CLUNIE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MORTON, H., HEGH, V. & CLUNIE, G. Immunosuppression detected in pregnant mice by rosette inhibition test. Nature 249, 459–460 (1974). https://doi.org/10.1038/249459a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/249459a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing