Abstract
CHEN and Giblett1 have reported the occurrence of genetic polymorphism for human red cell glutamic pyruvic transaminase (GPT; EC 2.6.1.2). The usual phenotypes of red cell GPT (that is, GPT 1, 2-1 and 2) could be identified on cellogel by adapting the starch gel electrophoretic method of Chen and Giblett to cellogel (Fraser et al., unpublished). When a buffer system which separates the human and Chinese hamster forms is used, however, the isozyme patterns formed by fibroblasts were found to be distinctly different from those by red cells. We have employed the fibroblast isozymes as markers in human gene linkage studies using man–Chinese hamster somatic cell hybrids and have reported that the enzyme with GPT activity is probably a tetramer determined by two genes named GPT B and GPT C located on different chromosomes and linked to LDH B and LDH A respectively2.
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References
Chen, S. H., and Giblett, E. R., Science, 173, 148 (1971).
Someren, H. van., Meera Khan, P., Westerveld, A., and Bootsma, D., Nature. new. Biol., 240, 221 (1972).
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VAN SOMEREN, H., KHAN, P., WESTERVELD, A. et al. Claim that two human linkage groups carry different loci for GPT and LDH withdrawn. Nature 249, 279–280 (1974). https://doi.org/10.1038/249279a0
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DOI: https://doi.org/10.1038/249279a0
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